Please note: Seating is on a first-come, first-served basis. According to fire code, a session must and will be closed if the room is filled to capacity.
7:15 - 8 a.m.
Council Awards Breakfast
Hall B 2
Annual Business
2007 Distinguished Achievement Award Presentation
Debate: Stenting vs. Endarterectomy for Carotid Stenosis
Moderator: Seemant Chaturvedi, M.D., Detroit, Mich.
Stenting: Pierre B. Fayad, M.D., FAHA, Omaha, Neb.
Endarterectomy: E. Sander Connolly, Jr., M.D., New York, N.Y.
8 - 8:10 a.m.
Short Break
8:10 - 9:40 a.m.
Session XI: Concurrent Symposia A
Impaired Glucose Metabolism: New Horizons for Improving Stroke Prevention and Vascular Outcomes
Hall B 2-2
Moderators:
Karen C. Johnston, M.D., M.S., FAHA, Charlottesville, Va.
Pierre B. Fayad, M.D., FAHA, Omaha, Neb.
8:10 The Epidemiology and Burden of Impaired Glucose Metabolism
David Tanne, M.D., Tel-hashomer, Israel
8:30 Pathophysiology of Impaired Glucose Metabolism and Vascular Disease
Silvio Inzucchi, New Haven, Conn.
8:50 Management of Impaired Glucose Metabolism in Acute Stroke
Askiel Bruno, M.D., M.S., FA, FAHA, Indianapolis, Ind.
9:10 Glycemic Control for Preventing Stroke and Vascular Disease
Walter Kernan, M.D., New Haven, Conn.
9:30 Discussion
Session XI: Concurrent Symposia B
Molecular Biology and Genetics of Brain Aneurysms and AVMs
Room RO-6
This session has been jointly organized by the American Stroke Association, AANS/CNS Cerebrovascular Section and the Society of NeuroInterventional Surgery.
Moderators:
Colin Derdeyn, M.D., FAHA, St. Louis, Mo.
Gregory J. Zipfel, M.D., St. Louis, Mo.
8:10 Molecular Biology of Brain AVMs
William L. Young, M.D., San Francisco, Calif.
8:30 Genetics of Brain AVMs - Hereditary Hemorrhagic Telangiectasia: Genetic Clues to the Pathophysiology of Brain AVMs
Michelle Letarte, Ph.D., Toronto, Canada
8:50 Cellular Response to Endovascular Aneurysm Treatment
David F Kallmes, M.D., Rochester, Minn.
9:10 Gene Therapy and Endovascular Treatment of Intracranial Aneurysms
Jean Raymond, M.D., Montreal, Canada
9:30 Discussion
Session XI: Concurrent C
Oral Abstract Presentations: Chairs' Choice I: High Profile Research That You Want to Know
Room La Louisianne A/B
Moderator:
Philip B Gorelick, M.D., M.P.H., FACP, Chicago, Ill.
8:10 Americans Have Higher Prevalence Of Stroke Than Europeans: Results From An International Study 120
Mauricio Avendano Dr., Erasmus MC -Public Health, Rotterdam, The Netherlands
8:22 Left Atrial Diameter Predicts Atrial Fibrillation in Ischemic Stroke Patients 121
Fabricio Lima, Massachusetts General Hosp, Boston, Mass.; Michael K. Parides, Columbia University, New York, N.Y.; David M. Greer, Massachusetts General Hospital, Boston, Mass.; Peter J. Kelly, Mater Misericordiae University Hospital, Dublin, Ireland; Karen L. Furie, Massachusetts General Hospital, Boston, Mass.
8:34 Ability of the ABCD2 Clinical Prediction Rule to Identify Low-Risk TIA Cases in Community-Based Emergency Departments 122
Mathew J. Reeves, Julia Warner Gargano, Susan Wehner, Michigan State University, East Lansing, Mich.; Michael Brown, MERC, Michigan State University, Grand Rapids, Mich.; Ted Glynn, Mary Hughes, Arshad Majid, Michigan State University, East Lansing, Mich.; Rashmi Kothari, Michigan State University, Kalamazoo, Mich.
8:46 Validation of a Swallow Screening Tool in Acute Neuroscience Patients 123
Tessa Goldsmith, Elizabeth Cadogan, Karen L. Furie, Lee H. Schwamm, Aneesh B. Singhal, Carmen Vega-Barachowitz, Hang Lee, Audrey Kurash Cohen, Massachusetts General Hospital, Boston, Mass.
8:58 Neurovascular Phenotypes Among Children with Ruptured Idiopathic Intracranial Arterial Aneurysms, and Comparison with the Adult Phenotype 124
Todd Abruzzo, University of Cincinnati Medical Center, Cincinnati, Ohio; Lynn Serrano, Cincinnati Children's Medical Center, Cincinnati, Ohio; H. Kocaeli, University of Cincinnati Medical Center, Cincinnati, Ohio; B. Jones, Cincinnati Children's Medical Center, Cincinnati, Ohio; N. Zumberge, Columbus Children's Hospital, Columbus, Ohio; F. Mangano, Cincinnati Children's Medical Center, Cincinnati, Ohio; M. Zuccarello, University of Cincinnati Medical Center, Cincinnati, Ohio
9:10 Stroke Risk Factors Are Predictive of Cognitive Decline in the Absence of Clinically Diagnosed Incident Stroke 125
George Howard, Virginia G. Wadley, University of Alabama Birmingham, Birmingham, Ala.; Frederick W. Unverzagt, Indiana University School of Medicine, Indianapolis, Ind.; Nancy Jenny, University of Vermont, Burlington, Vt.; Rodney C. Go, University of Alabama Birmingham, Birmingham, Ala.; Mary Cushman, University of Vermont, Burlington, Vt.; Claudia S. Moy, Natl Inst of Neurological Disorders and Stroke, Bethesda, MD; for the REasons for Geographic and Racial Differences in Stroke (REGARDS) Investigators
9:22 Variants in The Monocyte Chemoattractant Protein-1 (MCP-1) and Chemokine Receptor-2 (CCR2) Genes Act Synergistically to Increase the Risk of Carotid Atherosclerosis 126
Paul A. Nyquist, Johns Hopkins, Baltimore, Md.; Cherie A. Winkler, National Cancer Institute, Frederick, Md.; Louise M. McKenzie, National Cancer Institute, Baltimore, Md.; Lisa R. Yanek, Lewis C. Becker, Diane M. Becker, Johns Hopkins, Baltimore, Md.
9:34 Discussion
Session XI: Concurrent D
Oral Abstract Presentations: Acute Management II
La Louisianne C
Moderators:
Scott E. Kasner, M.D., FAHA, Philadelphia, Pa.
Katayoun Vahedi, Paris, France
8:10 Timing Of Microbubble-enhanced Sonothrombolysis Strongly Predicts Intracranial Hemorrhage In Acute Ischemic Stroke 127
Lavinia Dinia, Marta Rubiera, Marc Ribo, Estevo Santamarina, Olga Maisterra, Raquel Delgado-Mederos, Jorge Pagola, Jose Alvarez-Sabin, Joan Montaner, Carlos A Molina, Hosp Vall D Hebron, Barcelona, Spain
8:22 The Clinical Effect of Mild Hemorrhagic Transformation after Acute Intra-arterial Revascularization Therapy: An Exploratory Analysis 128
Pooja Khatri, University of Cincinnati, Cincinnati, Ohio; Renee' Martin, Medical University of South Carolina, Charleston, S.C.; Thomas A. Tomsick, University of Cincinnati, Cincinnati, Ohio; Yuko Y. Palesch, Medical University of South Carolina, Charleston, S.C.; Michael D. Hill, University of Calgary, Calgary, AB, Canada; Joseph P. Broderick, University of Cincinnati, Cincinnati, Ohio; for the IMS I and II Investigators
8:34 Implant For Augmentation Of Cerebral Blood Flow Clinical Trial-(ImpACT-1). An Interim Analysis Of Safety And Effectiveness Of The Neuropath Is System In The Treatment Of Acute Ischemic Stroke 129
Subhash Kaul, Nizam's Institute of Medical Sciences, Nizam, India; Dheraj Khurana, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Attila Csni, Petz Hosp, Gyor, Hungary; Nasli Ichaporia, Jehangir Hosp, Pune, India; Dietmar Schneider, Univ of Leipzig, Leipzig, Germany; Christoph Lichy, Heidelberg Univ Clinic, Heidelberg, Germany; Sagit Weiss, David Katz, Avinoam Dayan, BrainsGate LTD, Caesarea, Israel; Yoram Solberg, Brainsgate LTD, Caesarea, Israel; Menashe Levy, BrainsGate LTD, Caesarea, Israel; David Tanne, Chaim Sheba Medical Ctr, Tel-Hashomer, Israel; David Yarnitsky, Rambam hospital, Haifa, Israel; Marc Fisher, University of Massachusetts Medical School, Worcester, Mass.; Werner Hacke, Heidelberg University Clinic, Heideleberg, Germany; Natan Bornstein, Tel Aviv Medical Center, Tel Aviv, Israel
8:46 Good Outcome after Technically Successful Intra-Arterial Therapy is Time-Dependent 130
Pooja Khatri, Todd Abruzzo, University of Cincinnati, Cincinnati, Ohio; Sharon D. Yeatts, Medical University of South Carolina, Charleston, S.C.; Joseph P. Broderick, Thomas A. Tomsick, University of Cincinnati, Cincinnati, Ohio; for the IMS I and II Investigators
8:58 Number Needed To Treat Estimates For tPA Per 90-minute Time Interval 131
Maarten G. Lansberg, Stanford University, Palo Alto, Calif.; Erich Bluhmki, Boehringer Ingelheim, Ingelheim, Germany; Jeffrey L. Saver, UCLA, Los Angeles, Calif.
9:10 Quality Indicators For Primary Stroke Centers 132
Anna Bersano, Monica Gattinoni, Dept of Neurological Sciences Fondazione Ospedale Maggiore Policlinico, Milan, Italy; Alberto Morabito, Cattedra di Statistica medica, Univ of Milan, Milan, Italy; Roberto Sterzi, SC Neurologia, Ospedale Niguarda Ca' Granda, Milan, Italy; Giuseppe Micieli, UO Neurologia I/Stroke unit, Istituto Clinico Humanitas,Rozzano, Milan, Italy; Pierluigi Baron, Livia Candelise, Dept of Neurological Sciences Fondazione Ospedale Maggiore Policlinico, Milan, Italy
9:22 AX200 (G-CSF) for the Treatment of Acute Ischemic Stroke (AXIS) 133
Wolf R Schabitz, Department of Neurology, University, Munster, Germany; Rico Laage, Sygnis Bioscience, Heidelberg, Germany; Stefan Schwab, Department of Neurology, University, Erlangen, Germany; Dietmar Schneider, Department of Neurology, Univ, Leipzig, Germany; Gerhard Hamann, Department of Neurology, Wiesbaden, Germany; Michael Rosenkranz, Department of Neurology, University, Hamburg, Germany; Roland Veltkamp, Department of Neurology, University, Heidelberg, Germany; Marc Fisher, Department of Neurology, University, Massachusetts, Worcester, MA; Jim Grotta, Dept of Neurology, Univ, Texas, Houston, Texas; Werner Hacke, Department of Neurology, University, Heidelberg, Germany; Armin Schneider, Sygnis Bioscience, Heidelberg, Germany; for the AXIS study group
9:34 Discussion
Session XI: Concurrent E
Oral Abstract Presentations: Pathophysiology/Thrombosis
Room RO-2
Moderators:
Bruce M. Coull, M.D., FAHA, Tucson, Ariz.
Alastair Buchan, M.D., FAHA, Oxford, United Kingdom
8:10 Elevated Levels of Thrombin-Antithrombin (TAT) are Associated with Greater Stroke Severity in African American but not White Women 134
Cheryl Bushnell, Wake Forest University Health Sciences, Winston-Salem, N.C.; Thomas Ortel, Larry Goldstein, Duke University, Durham, N.C.
8:22 Higher Inflammatory Status in Patients with Posterior Circulation Stroke than in Those with Anterior Circulation Stroke 135
A-Hyun Cho, Catholic University, St. Mary's Hospital, Seoul, Republic of Korea; Sang Beom Jeon, Hyun-Sook Chi, Seongsoo Jang, Young-Uk Cho, Eugene Lee, Jong S. Kim, Asan Medical Center, Seoul, Republic of Korea
8:34 Cerebral Autoregulation And CO2 Reactivity In Small Vessel Disease Is Affected By Blood Pressure And Not By White Matter Disease Load 136
Jonathan Birns, King's College London School of Medicine, London, United Kingdom; Jozef Jarosz, King's College Hospital, London, United Kingdom; Hugh Markus, St. George's, University of London, London, United Kingdom; Lalit Kalra, King's College London School of Medicine, London, United Kingdom
8:46 Vulnerability Of Infratentorial White Matter To Nocturnal Decreases In Blood Pressure 137
Jonathan Birns, King's Coll London Sch of Med, London, United Kingdom; Jozef Jarosz, King's College Hospital, London, United Kingdom; Hugh Markus, St. George's, University of London, London, United Kingdom; Lalit Kalra, King's College London School of Medicine, London, United Kingdom
8:58 Magnitude And Time Course Of Platelet Inhibition With Extended Release Dipyridamole With Or Without Aspirin In Healthy Japanese Volunteers: The Japanese Aggrenox Versus Aspirin Therapy Evaluation (JAGATE) 138
Victor L. Serebruany, Alex Malinin, Osler Medical Center, Towson, Md.; Dan Hanley, Johns Hopkins University, Baltimore, Md.
9:10 Albumin Treatment Improves Microvascular Hemodynamics and Augments the Effect of Thrombolytic Therapy in Arteriolar Thrombosis: a Two-Photon Microscopy Study 139
Myron D. Ginsberg, Hee-Pyoung Park, Anitha Nimmagadda, Richard A. DeFazio, Raul Busto, Ricardo Prado, University Miami School of Medicine, Miami, Fla.
9:22 Scanning Electron Microscopy Analysis of Thromboembolic Material Retrieved from Cerebral and Cervical Arteries of Patients with Acute Ischemic Stroke 140
Raul G. Nogueira, Massachusetts General Hospital, Boston, Mass.; Sivaprasad Sukavaneshvar, Medical Device Evaluation Center, Salt Lake City, Utah; James D. Rabinov, Guilherme Dabus, Albert J. Yoo, Ferdinando S. Buonanno, Johnny C. Pryor, Lee H. Schwamm, Joshua A. Hirsch, Massachusetts General Hospital, Boston, Mass.
9:34 Discussion
9:40 - 9:50 a.m.
Short Break
9:50 - 11:20 a.m.
Session XII: Concurrent Symposia A
The Ischemic Penumbra: Cellular Concepts to Clinical Trials
Room La Louisianne C
Moderators:
Midori A. Yenari, M.D., San Francisco, Calif.
Chelsea Kidwell, M.D., Washington, D.C.
9:50 Introduction
9:55 New Molecular Targets in the Ischemic Penumbra
Frank Sharp, B.S., M.D., Sacramento, Calif.
10:10 Neurovascular Signaling in the Experimental Penumbra
Cenk Ayata, M.D., Boston, Mass.
10:25 Multimodality MRI of Experimental Stroke
Timothy Duong, Atlanta, Ga.
10:45 Assessing the Penumbra for Clinical Trials
Stephen M. Davis, M.D., M.B.B.S., FRCP, Melbourne, Australia
11:10 Discussion
Session XII: Concurrent Symposia B
Cavernous Malformations
Room RO-6
This session has been jointly organized by the American Stroke Association, AANS/CNS Cerebrovascular Section and the Society of NeuroInterventional Surgery.
Moderators:
Jacques Morcos, M.D., Miami, Fla.
Charles Prestigiacomo, M.D., Newark, N.J.
9:50 Molecular Genetics and Natural History
Murat Gunel, M.D., FACS, New Haven, Conn.
10:07 Natural History and Radiosurgery
Douglas Kondziolka, Pittsburgh, Pa.
10:24 Supratentorial Lesions
Issam A. Awad, M.D., M.Sc., FACS, M.A., Evanston, Ill.
10:41 Infratentorial Lesions - Skull Base Approaches
Michael Lawton, M.D., San Francisco, Calif.
10:58 Case Presentations/Discussion
Session XII: Concurrent C
Oral Abstract Presentations: Chairs' Choice II: A Last Taste of Research at ISC 2008
Room La Louisianne A/B
Moderators:
Patricia D. Hurn, Ph.D., FAHA, Portland, Ore.
Lewis B. Morgenstern, M.D., Ann Arbor, Mich.
9:50 TNK Induces Faster MCA Recanalization and leads to Better Short- and Long-term Clinical Outcome Than Native tPA. The TNK-TPA Reperfusion Stroke Study 141
Carlos A. Molina, Marc Ribo, Marta Rubiera, Estevo Santamarina, Raquel Delgado-Mederos, Olga Maisterra, Pilar Delgado, Lavinia Dinia, Octavio Pontes, Joan Montaner, Jos Alvarez-Sabin, Hosp Vall d Hebron, Barcelona, Spain
10:02 Mr Guided Focused Ultrasound Surgery For The Treatment Of Intra Cerebral Hemorrhage: In Vitro Proof Of Concept 142
Sagi Harnof, University of Virginia, Charlottesville, Va.; Arik Hananel, Gilat Schiff, Javier Grinfeld, Eyal Zadicario, Insightec, Haifa, Israel; Neal Kassell, University of Virginia, Charlottesville, Va.
10:14 Stent Or Surgery In Symptomatic Carotid Artery Stenosis - Age Is An Important Factor To Consider 143
Robert Stingele, Karsten Alfke, UKSH Kiel, Kiel, Germany; The SPACE Study Group
10:26 VECTORS (Very Early Constraint Therapy for Recovery from Stroke) Phase II RCT: Results of Secondary Analyses 144
Dorothy F. Edwards, University of Wisconsin, Madison, Wis.; Catherine E. Lang, Rebecca Birkenmeier, Washington University, St. Louis, Mo.; William J. Powers, University of North Carolina, Chapel Hill, N.C.; Alexander W. Dromerick, Georgetown University and National Rehabilitation Hospital, Washington, D.C.
10:38 High Resolution Copy Number Variation Analysis of Sporadic and Familial CCM Patients 146
Yasar Bayri, Winson S. Ho, Kaya Bilguvar, Michael DiLuna, Mohamad Bydon, Lindsay A. Collins, Fatih Bayrakli, Christopher E. Mason, Matthew W. State, Murat Gunel, Yale University School of Medicine, New Haven, Conn.
10:50 Transplantation Of Adipose Tissue-derived Stem Cells In Cerebral Ischemia: Enhanced Angiogenesis By Functional Stem Cells And Feasibility Of Autologous Transplantation 147
Kon Chu, Soon-Tae Lee, Keun-Hwa Jung, Eun-Cheol Song, Hee-Kwon Park, Jeong-Min Kim, Jin-Hee Kim, Jae-Sung Lim, Kyung-Mook Kang, Nan-Hyung Hong, Jun-Young Chang, Sang Kun Lee, Manho Kim, Jae-Kyu Roh, Seoul National University Hospital, Seoul, Republic of Korea
11:02 Cortical Stimulation for Upper-Extremity Hemiparesis from Ischemic Stroke: Everest Study Primary Endpoint Results 162
Robert M. Levy, Northwestern University, Chicago, Ill.; Randall R. Benson, Wayne State University, Detroit, Mich.; Carolee J. Winstein, University of Southern California, Los Angeles, Calif.; Everest Study Investigators
11:14 Discussion
Session XII: Concurrent D
Oral Abstract Presentations: Diagnosis
Hall B 2-2
Moderator:
Lawrence Wong, M.D., FAHA, Shatin, Hong Kong
9:50 18FDG-PET Imaging Of Human Carotid Arteries Prior To Endarterectomy Confirms It Is A Bilateral Disease 148
M.Angels Font, Hosp Univri de Bellvitge, Barcelona, Spain; Alex Fernandez, Cristina Gamez, Hosp Univri de Bellvitge, IDI, Barcelona, Spain; Mark Slevin, Manchester Metropolitan Univ, Manchester, United Kingdom; Ramon Vila, Elena Iborra, Hosp Univri de Bellvitge, ACV, Barcelona, Spain; Francisco Rubio, Jerzy Krupinski, Hosp Univri de Bellvitge, Barcelona, Spain
10:02 CT and MRI Early Vessel Signs Reflect Clot Composition in Acute Stroke 149
David S. Liebeskind, William H. Yong, Nerses Sanossian, Sidney Starkman, Michael P. Tsang, Antonio L. Moya, David D. Zheng, Doojin Kim, Latisha K. Ali, Samir H. Shah, Amytis Towfighi, Bruce Ovbiagele, UCLA, Los Angeles, Calif.; Chelsea S. Kidwell, Georgetown University, Washington, D.C.; Satoshi Tateshima, Reza Jahan, Gary R. Duckwiler, Fernando Vinuela, Noriko Salamon, J. Pablo Villablanca, Victor J. Marder, Jeffrey L. Saver, UCLA, Los Angeles, Calif.
10:14 Evaluation Of Patients With Suspected Cardioembolic Stroke Using Cardiovascular Mri - A Comparative Study With Echocardiography 150
John J. Sheehan, Northwestern Memorial Hospital, Chicago, Ill.; George Lin, Northwestern University, Chicago, Ill.; Jim Connors, Mark J. Alberts, Karin Dill, Reed A. Omary, Richard Bernstein, James C. Carr, Northwestern Memorial Hospital, Chicago, Ill.
10:26 Prognostic Value of a Qualitative MRI Scoring System for Neurologic Outcome of Comatose Survivors After Cardiac Arrest 151
Sofie Jansen, Department of Neurology and Neurological Sciences, Stanford Stroke Center, Stanford University Medical Center, Stanford, Calif.; Nancy J. Fischbein, Michael V. Krasnokutsky, Department of Radiology, Stanford University Medical Center, Stanford, Calif.; Michael Mlynash, Irina Eyngorn, Christine AC Wijman, Department of Neurology and Neurological Sciences, Stanford Stroke Center, Stanford University Medical Center, Stanford, Calif.
10:38 CT Angiography Source Images Predict Functional Outcome In Basilar Artery Occlusion: The Posterior Circulation Acute Stroke Prognosis Early CT Score 152
Volker Puetz, University of Calgary, Calgary, AB, Canada; P.N. Sylaja, Ananthapuri Hospital and Research Institute, Trivandrum, India; Michael D. Hill, Shelagh B. Coutts, University of Calgary, Calgary, AB, Canada; Imanuel Dzialowski, Pia Mueller, Ulf Becker, Technical Univ Dresden, Dresden, Germany; Philip A. Barber, Mayank Goyal, Pranshu Sharma, Univ of Calgary, Calgary, AB, Canada; Georg Gahn, Ruediger von Kummer, Technical University Dresden, Dresden, Germany; Andrew M. Demchuk, University of Calgary, Calgary, AB, Canada
10:50 Cervicocepharic Arterial Dissections in Japan: Analysis of 454 patients in the Spontaneous Cervicocephalic Arterial Dissections Study I (SCADS-I) 153
Kazuo Minematsu, Hideki Matsuoka, Junji Kasuya, National Cardiovascular Center, Suita, Osaka, Japan; SCADS-I collaborators
11:02 Emergent Echocardiography Is Associated With A High Rate Of Detection Of Mobile Aortic Arch Thrombi In Acute Ischemic Stroke 154
Estevo Santamarina, M. Teresa Gonzalez-Alujas, Andrea Pacchioni, Marc Ribo, Marta Rubiera, Olga Maisterra, Raquel Delgado-Mederos, Pilar Delgado, Jose Alvarez Sabin, Carlos A. Molina, Hospital Vall Hebron, Barcelona, Spain
11:14 Discussion
Session XII: Concurrent E
Oral Abstract Presentations: Cerebrovascular Vessel Biology
Room RO-2
Moderators:
Colin Derdeyn, M.D., FAHA, St. Louis, Mo.
Gregory J. Zipfel, M.D., St. Louis, Mo.
9:50 The Balance Between The Expression Of Cd36 And Abca1 Favors Lipid Accumulation In Ulcerated Carotid Plaques 155
Pia M. Isoviita, Krista Nuotio, Riitta Turunen, Jani Saksi, Petra, Biomedicum Helsinki, Helsinki, Finland; Petri Kovanen, Wihuri Research Institute, Helsinki, Finland; Markku Kaste, Perttu J. Lindsberg, Department of Neurology, Helsinki, Finland
10:02 C-reactive Protein Exerts Potent Angiogenic Effects On Vascular Endothelial Cells 156
Jerzy Krupinski, Marta M. Turu, Hosp Univri de Bellvitge,, Barcelona, Spain; Sabine Matou, Manchester Metropolitan Univ, Manchester, United Kingdom; Cristina Rodriguez, Jose Martinez-Gonzalez, Lina Badimon, CSIC-ICCC, Barcelona, Spain; Ana Luque, Hosp Univri de Bellvitge, Barcelona, Spain; Mark Slevin, Manchester Metropolitan Univ, Manchester, United Kingdom
10:14 Early Blood Brain Barrier Disruption Is Associated With Plasma Matrix Metalloproteinase-9 Concentration In Acute Stroke Patients 157
Taura L. Barr, National Institutes of Neurological Disorders and Stroke, National Institute of Nursing Research, National Institutes of Health, Bethesda, Md.; Lawrence L. Latour, Kyung-Yul Lee, Timothy J. Schaewe, Marie Luby, George Chang, Ziad El-Zammar, Shaista Alam, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md.; Chelsea S. Kidwell, Georgetown University, Washington, D.C.; Steven Warach, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md.; for the NIH Natural History of Stroke Investigators
10:26 Regional Differences In CO2 Vasoreactivity After Stroke Using CASL MRI 158
Peng Zhao, David Alsop, Magdy Selim, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.; Amir Abduljalil, The Ohio State University, Columbus, Ohio; Peter Novak, University of Massachusetts, Boston, Mass.; Lewis Lipsitz, Kun Hu, Sarah LaRose, Vera Novak, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.
10:38 Granulocyte-Macrophage Colony-Stimulating Factor Treatment after Common Carotid Artery Occlusion Enhances Leptomeningeal Collateral Growth and Reduces Infarct Size after Focal Cerebral Ischemia 159
Kenichi Todo, Kazuo Kitagawa, Tsutomu Sasaki, Emi Omura-Matsuoka, Yasukazu Terasaki, Naoki Oyama, Yoshiki Yagita, Masatsugu Hori, Osaka University, Osaka, Japan
10:50 Interference with Peroxisome Proliferator-activated Receptor Gamma Signaling Causes Cerebral Vascular Hypertrophy and Remodeling 160
Gary L. Baumbach, Carmen M. Halabi, Andreas M. Beyer, Curt D. Sigmund, Frank M. Faraci, University of Iowa, Iowa City, Iowa
11:02 Genome Wide Association Study of Intracranial Aneurysms in the Finnish Population 161
Kaya Bilguvar, Yasar Bayri, Michael DiLuna, Fatih Bayrakli, Christopher E. Mason, Mohamad Bydon, Yale University School of Medicine, New Haven, Conn.; Mika Niemela, Aki Laakso, Juha Hernesniemi, Helsinki University School of Medicine, Helsinki, Finland; Juha E. Jaaskelainen, University of Kuipio, Kuipio, Finland; Aarno Palotie, Helsinki University School of Medicine, Helsinki, Finland; Jaakko Rinne, University of Kuopio, Kuopio, Finland; Matthew W. State, Murat Gunel, Yale University School of Medicine, New Haven, Conn.
11:14 Discussion
11:20 - 11:30 a.m.
Short Break
11:30 - 1 p.m.
Session XIII: Plenary Session III
Late-Breaking Science Oral Abstracts
Hall B 2
Moderators:
Venkatesh Aiyagari, M.B.B.S., Chicago, Ill.
Sean Ruland, Chicago, Ill.
11:30 Results of EPITHET: Effects of tPA Beyond 3 Hours on Infarct Growth, Reperfusion and Clinical Outcomes LB 1
Stephen M. Davis, Royal Melbourne Hospital, Melbourne, Australia; Geoffrey A. Donnan, National Stroke Research Institute,
Melbourne, Australia; Deidre A De Silva, Royal Melbourne Hosp, Melbourne, Australia; Kenneth S. Butcher, University of Alberta, Alberta, AB, Canada; Mark Parsons, Christopher Levi, John Hunter Hospital, Newcastle, Australia; Alan Barber, Auckland Hospital, Auckland, New Zealand; Christopher Bladin, Box Hill Hospital, Melbourne, Australia; Graham Byrnes, University of Melbourne, Melbourne, Australia; Andre Peeters, University Hospital
St. Luc, Brussels, Belgium; Jonathan Chalk, Royal Brisbane Hospital, Brisbane, Australia; David Schultz, Flinders Medical Center, Adelaide, Australia; John Fink, Christchurch Hospital, Christchurch, New Zealand; Thomas Kimber, Royal Adelaide Hosp, Adelaide, Australia; for the Echoplanar Imaging Thrombolytic EvaluationTrial (EPITHET) Investigators
11:40 Control of Hypertension and Hypotension Immediately Post-Stroke (CHHIPS) Pilot Trial LB 2
John F. Potter, University of East Anglia, Norwich, United Kingdom
11:50 The Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT): Results of the Vanguard Phase LB 3
Craig Anderson, The George Institute for International Health, University of Sydney, NSW, Australia; Yining Huang, Peking University First Hospital, Peking University, China; Jiguang Wang, Shanghai Institute of Hypertension, Rui Jin Hospital, China; Hisatomi Arima, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Bruce Neal, The George Institute for International Health, University of Sydney, NSW, Australia; Bin Peng, Peking Union Medical College, Beijing, China; Emma Heeley, Christian Skulina, The George Institute for International Health, University of Sydney, NSW, Australia; Mark Parsons, John Hunter Hospital, University of Newcastle, NSW, Australia; Jong Sung Kim, Asan Medical Center, University of Ulsan, Seoul, Republic of Korea; Stephane Heritier, The George Institute for International Health, University of Sydney, NSW, Australia; Lewis Morgenstern, University of Michigan Medical School, Ann Arbor, Mich.; John Chalmers, The George Institute for International Health, University of Sydney, NSW, Australia
12:00 The Penumbra Stroke Trial: Safety and Effectiveness of a New Generation of Mechanical Devices for Clot Removal in Acute Ischemic Stroke LB 4
C. McDougall, Barrow Neurological Institute, Phoenix, Ariz.; W. Clark, Oregon Health and Science University, Portland, Ore.; T. Mayer, Ludwig Maximilians University Munchen, Munich, Germany; A. Doerfler, Univsklinikum Erlangen, Erlangen, Germany; I. Grunwald, Univsklinikum des Saarlandes, Homburg, Germany; J. Berkefeld, Klinikum der Johann Wolfgang Goethe Univ Frankfurt, Frankfurt, Germany; D. Lopes, Rush University Medical Center, Chicago, Ill.; H. Shownkeen, Central Dupage Hosp, Winfield, Ill.; M. Madison, St. Joseph’s Hospital, St. Paul, Minn.; R. Budzik, Riverside Methodist Hospital, Columbus, Ohio; D. Heck, Forsyth Radiological Associates, Winston-Salem, N.C.; D. Frei, Swedish Medical Center, Englewood, Colo.; O. Zaidat, Medical College of Wisconsin, Milwaukee, Wis.; V. Branca, Ospedale Maggiore Milano, Milan, Italy; N. Ahktar, St. Luke’s Hospital, Kansas City, Mo.; A. Rai, West Virginia University Hospital, Morgantown, W.Va.; J. Chaloupka, University of Iowa Hospital, Iowa City, Iowa; F. Hellinger, Florida Hospital, Orlando, Fla.; P. Rasmussen, Cleveland Clinic, Cleveland, Ohio; S. Rudolph, Maimonides Medical Center, Brooklyn, N.Y.; G. Spiegel, Hartford Hospital, Hartford, Conn.
12:10 Donepezil in Subcortical Vascular Cognitive Impairment: A Randomized Double Blind Trial in CADASIL LB 5
Martin Dichgans, Ludwig-Maximilians-Univ, Muenchen, Germany; Hugh S Markus, St. George’s University of London, London, United Kingdom; Stephen Salloway, Brown Medical School, Providence, R.I.; Margaret Moline, Qin Wang, Eisai Medical Research, Ridgefield Park, N.J.; Holly Posner, Pfizer, Inc., New York, N.Y.; Hugues Chabriat, Hop Lariboisiere, APHP, INSERM U740, Paris, France
12:20 Genome-Wide SNP Linkage Screen for Intracranial Aneurysm Susceptibility Genes: Results from 333 Multiplex IA Families LB 6
Tatiana Foroud, Daniel Koller, Dongbing Lai, Indiana University, Indianapolis, Ind.; Daniel Woo, Laura Sauerbeck, University of Cincinnati, Cincinnati, Ohio; Richard Hornung, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio; David Wiebers, Mayo Clinic, Rochester, Minn.; E. Sander Connolly, Columbia University, New York, N.Y.; Craig Anderson, University of Sydney, Sydney, Australia; Guy Rouleau, Notre Dame Hospital, Montreal, QC, Canada; Ranjan Deka, University of Cincinnati, Cincinnati, Ohio; Irene Meissner, Mayo Clinic, Rochester, Minn.; Joan Bailey-Wilson, National Human Genome Research Institute, Baltimore, Md.; John Huston, Robert Brown, Mayo Clinic, Rochester, Minn.; Joseph Broderick, University of Cincinnati, Cincinnati, Ohio; FIA Investigators
12:30 Discussion
1:00 ADJOURN
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